Guide to Paracetamol Poisoning in Cats & Dogs
Paracetamol is highly toxic to both dogs and cats, but cats are uniquely sensitive to its toxic effects.
In humans, the liver safely metabolises paracetamol into non-toxic compounds. Dogs and cats, however, lack sufficient quantities of the necessary enzymes to complete this process. As a result, toxic compounds accumulate and cause severe oxidative damage.
Cats are the most vulnerable species to paracetamol toxicity because their red blood cells are more susceptible to oxidative damage.
Written by Dr. Mariella Roberts, Veterinary Surgeon, Animal Trust Vets CIC | Published July 2025 | Review date July 2028 | This advice is for UK pets only and is not a replacement for seeing a vet
Symptoms of paracetamol poisoning in cats & dogs
When to contact your vet
Any suspected ingestion requires immediate veterinary attention. Tell your vet what painkiller was ingested, how much, and when.
Diagnosis
History and clinical examination
Blood and urine tests
Treatment of paracetamol poisoning in cats & dogs
Treatment depends on the severity of the poisoning and how soon medical intervention begins.
Inducing vomiting or administering activated charcoal (liquid to swallow) to reduce absorption may be done if the ingestion was recent
Supportive care with drip fluids, liver protectants, oxygen therapy, and blood transfusions may be required
Antidote therapy (N-acetylcysteine) is given to counter the toxic effects
Prevention
Never give paracetamol to your pet
Store all medications securely out of your pet's reach
Outlook
The outlook for paracetamol (acetaminophen) toxicity in dogs and cats varies significantly depending on the species, the amount ingested, and how quickly treatment is started. Cats are far more sensitive to paracetamol than dogs, making their outlook considerably more guarded.