Guide to Ibuprofen Poisoning in Cats & Dogs
Ibuprofen poisoning in dogs: ibuprofen blocks an enzyme (called cyclooxygenase) that, in addition to reducing inflammation, also has roles in promoting blood flow through the kidneys and producing protective inflammatory chemicals (called prostaglandins) for the lining of the stomach. Dogs are much more sensitive to the effects of ibuprofen than humans.
Ibuprofen poisoning in cats: cats are more sensitive than dogs, and they can be toxically affected by even the smallest dosage of ibuprofen; they are more sensitive to NSAIDs, in contrast to some other animals. Their brain, stomach and guts, and kidneys are likely to be affected by the drug’s effects.
Written by Dr. Mariella Roberts, Veterinary Surgeon, Animal Trust Vets CIC | Published July 2025 | Review date July 2028 | This advice is for UK pets only and is not a replacement for seeing a vet
Symptoms of ibuprofen poisoning in cats & dogs
Symptoms can show up a few hours after use, but they can also last for many days
Lethargy or weakness
Vomiting (with or without blood)
Not eating
Abdominal pain
Seizures or disorientation
Excessive thirst and urination (evidence of kidney damage)
Black, tarry stools (indicating internal bleeding)
When to contact your vet
If your pet has eaten ibuprofen, then you should contact your vet immediately. Symptoms can range from mild stomach and guts upset to severe organ damage and even death. To help your vet, have ready some information such as how much was ingested, and when it was eaten.
Diagnosis
History and clinical examination
Blood and urine tests
Treatment of ibuprofen poisoning in cats & dogs
Decontamination: if ingestion was recent, your vet may induce vomiting or administer activated charcoal (a liquid to swallow) to prevent further absorption.
Hospitalisation and supportive care: your pet may need a fluid drip (intravenous (IV) fluids) for at least 48 hours to support kidney function and maintain hydration.
Symptom management: anti-nausea medications and anti-seizure drugs may be given as needed.
Protective medications: The vet will administer medications to protect the guts and prevent or heal ulcers.
Blood transfusions: in severe cases with significant internal bleeding, a blood transfusion may be necessary.
Prevention
Never give your pet any human medication unless specifically instructed by your vet.
Store all medications safely, including over-the-counter drugs like ibuprofen, out of your pet's reach.
Consider pet-safe alternatives if your pet is in pain, consult your vet. We can prescribe species-appropriate anti-inflammatory (NSAIDs) that are safe for animals.
Outlook
The outlook is good if your pet has ingested not a too high dose of ibuprofen and if the treatment has started promptly as this will help prevent the effects on the guts and kidney.
The outlook is more uncertain if your pet has kidney disease or he/she is dehydrated.
A massive overdose can result in severe symptoms and poor outlook.